Spravato vs. Ketamine Therapy in San Diego — What’s the Difference?

Spravato vs. Ketamine Therapy in San Diego — What’s the Difference?

August 22, 2025

Ketamine-Based Treatments in San Diego

Ketamine therapy and Spravato® (esketamine) have gained attention as breakthrough treatments for depression and anxiety. At our Rancho Bernardo clinic in San Diego County, clients often ask: What’s the difference between the two?

What is Spravato?

Spravato® is an FDA-approved nasal spray used for treatment-resistant depression.

Key features:

  • Administered under supervision in clinic.
  • Insurance may cover part of the cost.
  • Strict dosing and frequency guidelines.

For some San Diego clients, Spravato is an accessible first step because of its approval and insurance coverage.

What is Ketamine Therapy?

Ketamine therapy at Velara Wellness uses IV or IM administration with racemic ketamine.

Key benefits:

  • Broader applications (PTSD, anxiety, OCD).
  • Often deeper, more transformative experiences.
  • Flexible, customized dosing.

Many clients in Rancho Bernardo and greater San Diego choose ketamine therapy for its immersive and versatile nature.

Comparing Spravato and Ketamine Therapy

  • Delivery: Spravato is nasal spray; ketamine is IV/IM.
  • Molecule: Spravato is esketamine; ketamine includes both molecules.
  • Experience: Spravato is shorter and milder; ketamine can be deeper and longer-lasting.
  • Coverage: Spravato may be covered by insurance; ketamine therapy is usually self-pay.

Which Should You Choose?

Your choice depends on treatment goals, insurance, and personal preference. In San Diego County, both options are available at Velara Wellness, where we guide clients through selecting the right path.

Key Takeaway

Spravato and ketamine therapy both have unique strengths. At Velara Wellness in Rancho Bernardo, we help clients understand their options and begin treatment with clarity.